View source for 8wuy


==Crystal Structure of TR3 LBD in complex with para-positioned 3,4,5-trisubstituted benzene derivatives==
<StructureSection load='8wuy' size='340' side='right'caption='[[8wuy]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8wuy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WUY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WUY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XBF:~{N}-methyl-~{N}-octyl-3,4,5-tris(oxidanyl)benzamide'>XBF</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wuy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wuy OCA], [https://pdbe.org/8wuy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wuy RCSB], [https://www.ebi.ac.uk/pdbsum/8wuy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wuy ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.<ref>PMID:15466594</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chen XQ]]
[[Category: Hong WB]]
[[Category: Lin TW]]