View source for 8wwx


==Ube1L acts akin to a mitt, that mediates UbcH8 binding and orchestrates "E1-E2" interaction==
<StructureSection load='8wwx' size='340' side='right'caption='[[8wwx]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8wwx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WWX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WWX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wwx OCA], [https://pdbe.org/8wwx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wwx RCSB], [https://www.ebi.ac.uk/pdbsum/8wwx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wwx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/UBA7_HUMAN UBA7_HUMAN] Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein.<ref>PMID:16254333</ref> <ref>PMID:20133869</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Dag C]]
[[Category: Elgin ES]]
[[Category: Lee W]]
[[Category: Ziarek JJ]]