View source for 8wx1


==Cryo-EM structure of mouse SLC15A3 (outward-facing open)==
<StructureSection load='8wx1' size='340' side='right'caption='[[8wx1]], [[Resolution|resolution]] 3.64&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8wx1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WX1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WX1 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.64&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wx1 OCA], [https://pdbe.org/8wx1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wx1 RCSB], [https://www.ebi.ac.uk/pdbsum/8wx1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wx1 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/S15A3_MOUSE S15A3_MOUSE] Proton-coupled amino-acid transporter that transports free histidine and certain di- and tripeptides, and is involved in innate immune response (PubMed:24695226). Also able to transport carnosine (By similarity). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (PubMed:24695226).[UniProtKB:Q8IY34]<ref>PMID:24695226</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Kasai S]]
[[Category: Ohto U]]
[[Category: Shimizu T]]
[[Category: Zhang Z]]