View source for 8wxj


==human CLC-1 D136G closed state==
<StructureSection load='8wxj' size='340' side='right'caption='[[8wxj]], [[Resolution|resolution]] 2.68&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8wxj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WXJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WXJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.68&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wxj OCA], [https://pdbe.org/8wxj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wxj RCSB], [https://www.ebi.ac.uk/pdbsum/8wxj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wxj ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/CLCN1_HUMAN CLCN1_HUMAN] Thomsen and Becker disease. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/CLCN1_HUMAN CLCN1_HUMAN] Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.<ref>PMID:12456816</ref> <ref>PMID:22521272</ref> <ref>PMID:26007199</ref> <ref>PMID:26502825</ref> <ref>PMID:26510092</ref> <ref>PMID:7951242</ref> <ref>PMID:8112288</ref> <ref>PMID:9122265</ref> <ref>PMID:9736777</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Zhang MF]]