View source for 8x87


==The Crystal Structure of HspBP1 from Biortus.==
<StructureSection load='8x87' size='340' side='right'caption='[[8x87]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8x87]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8X87 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8X87 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8x87 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8x87 OCA], [https://pdbe.org/8x87 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8x87 RCSB], [https://www.ebi.ac.uk/pdbsum/8x87 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8x87 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HPBP1_HUMAN HPBP1_HUMAN] Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.<ref>PMID:9830037</ref> <ref>PMID:10786638</ref> <ref>PMID:12651857</ref> <ref>PMID:15215316</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cheng W]]
[[Category: Lv Z]]
[[Category: Meng Q]]
[[Category: Wang F]]
[[Category: Xu Y]]