View source for 8x91


==P/Q type calcium channel in complex with omega-conotoxin MVIIC==
<StructureSection load='8x91' size='340' side='right'caption='[[8x91]], [[Resolution|resolution]] 3.11&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8x91]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_magus Conus magus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8X91 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8X91 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.11&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PE:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>3PE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PT5:(1S)-2-{[(R)-HYDROXY{[(1R,2R,3S,4R,5R,6S)-2,3,6-TRIHYDROXY-4,5-BIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL]OXY}-1-[(OCTADECANOYLOXY)METHYL]ETHYL+(8E,11E)-ICOSA-5,8,11,14-TETRAENOATE'>PT5</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8x91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8x91 OCA], [https://pdbe.org/8x91 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8x91 RCSB], [https://www.ebi.ac.uk/pdbsum/8x91 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8x91 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CACB3_HUMAN CACB3_HUMAN] Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8119293). Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity).[UniProtKB:P54287][UniProtKB:Q9MZL3]<ref>PMID:8119293</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Conus magus]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cong Y]]
[[Category: Li Z]]
[[Category: Wang T]]
[[Category: Wu T]]
[[Category: Yan N]]