View source for 8xif


==The crystal structure of the AEP domain of VACV D5==
<StructureSection load='8xif' size='340' side='right'caption='[[8xif]], [[Resolution|resolution]] 1.39&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8xif]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XIF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XIF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.39&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xif FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xif OCA], [https://pdbe.org/8xif PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xif RCSB], [https://www.ebi.ac.uk/pdbsum/8xif PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xif ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PG117_VACCW PG117_VACCW] Multifunctional protein required for genome uncoating and replication (PubMed:17093187, PubMed:18000036, PubMed:26912611). Major viral uncoating protein that is required for the release of the viral genome from incoming viral cores containing the viral DNA genome (PubMed:24439902). Possesses an ATPase activity that is required for hexamerization and uncoating (PubMed:24439902, PubMed:26912611).<ref>PMID:12490386</ref> <ref>PMID:17093187</ref> <ref>PMID:18000036</ref> <ref>PMID:24439902</ref> <ref>PMID:26912611</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Vaccinia virus]]
[[Category: Gan J]]
[[Category: Zhang W]]