View source for 8xir


==Structure of pasireotide-SSTR3 G protein complex==
<StructureSection load='8xir' size='340' side='right'caption='[[8xir]], [[Resolution|resolution]] 2.52&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8xir]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Lama_glama Lama glama] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XIR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XIR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.52&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=004:(2S)-AMINO(PHENYL)ETHANOIC+ACID'>004</scene>, <scene name='pdbligand=A1D5E:(2~{S},4~{R})-4-(2-azanylethylcarbamoyloxy)pyrrolidine-2-carboxylic+acid'>A1D5E</scene>, <scene name='pdbligand=DTR:D-TRYPTOPHAN'>DTR</scene>, <scene name='pdbligand=TY5:O-BENZYL-L-TYROSINE'>TY5</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xir OCA], [https://pdbe.org/8xir PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xir RCSB], [https://www.ebi.ac.uk/pdbsum/8xir PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xir ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SSR3_HUMAN SSR3_HUMAN] Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.<ref>PMID:1337145</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Lama glama]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Wang Y]]
[[Category: Xu HE]]
[[Category: Xu Y]]
[[Category: Zhuang Y]]