View source for 8xmb


==NTP-bound Pol IV transcription elongation complex==
<StructureSection load='8xmb' size='340' side='right'caption='[[8xmb]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8xmb]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XMB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XMB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xmb OCA], [https://pdbe.org/8xmb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xmb RCSB], [https://www.ebi.ac.uk/pdbsum/8xmb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xmb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NRPD1_ARATH NRPD1_ARATH] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity). Largest and catalytic component of RNA polymerase IV which mediates 24-nt short-interfering RNAs (siRNA) accumulation. Implicated in siRNA-directed heterochromatin formation through the action of DCL3 and AGO4, and subsequent DNA methylation-dependent silencing of targeted sequences. Essential component of a self-reinforcing loop coupling de novo DNA methylation to siRNA production. Required for intercellular but not intracellular RNA interference (RNAi) leading to systemic post-transcriptional gene silencing. Involved in the maintenance of post-transcriptional RNA silencing.<ref>PMID:10850496</ref> <ref>PMID:12198169</ref> <ref>PMID:15692015</ref> <ref>PMID:15766525</ref> <ref>PMID:16140984</ref> <ref>PMID:16273107</ref> <ref>PMID:16377568</ref> <ref>PMID:16839878</ref> <ref>PMID:17360559</ref> <ref>PMID:17526749</ref> <ref>PMID:17558406</ref> <ref>PMID:17785412</ref> <ref>PMID:18287047</ref> <ref>PMID:18433438</ref> <ref>PMID:18467467</ref> <ref>PMID:19110459</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Large Structures]]
[[Category: Fang CL]]
[[Category: Huang K]]
[[Category: Zhang Y]]