View source for 8xrh


==The crystal structure of AsfvTopII ATPase domain in complex with AMPPNP==
<StructureSection load='8xrh' size='340' side='right'caption='[[8xrh]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8xrh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/African_swine_fever_virus_BA71V African swine fever virus BA71V]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XRH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XRH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xrh OCA], [https://pdbe.org/8xrh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xrh RCSB], [https://www.ebi.ac.uk/pdbsum/8xrh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xrh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TOP2_ASFB7 TOP2_ASFB7] Type II topoisomerase (PubMed:25463606, PubMed:27060564). Processively relaxes supercoiled DNA (PubMed:27060564). Displays DNA-supercoiling activity only when associated with the viral histone-like protein (PubMed:28381576).<ref>PMID:25463606</ref> <ref>PMID:27060564</ref> <ref>PMID:28381576</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: African swine fever virus BA71V]]
[[Category: Large Structures]]
[[Category: Gan JH]]
[[Category: Yang J]]