View source for 8xsn


==transporter==
<StructureSection load='8xsn' size='340' side='right'caption='[[8xsn]], [[Resolution|resolution]] 3.29&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8xsn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XSN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XSN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.29&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RBF:RIBOFLAVIN'>RBF</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xsn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xsn OCA], [https://pdbe.org/8xsn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xsn RCSB], [https://www.ebi.ac.uk/pdbsum/8xsn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xsn ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/S52A3_HUMAN S52A3_HUMAN] RFVT3-related riboflavin transporter deficiency. The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/S52A3_HUMAN S52A3_HUMAN] Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism (PubMed:20463145, PubMed:22273710, PubMed:24264046, PubMed:27702554). Humans are unable to synthesize vitamin B2/riboflavin and must obtain it via intestinal absorption (PubMed:20463145).<ref>PMID:20463145</ref> <ref>PMID:22273710</ref> <ref>PMID:24264046</ref> <ref>PMID:27702554</ref> <ref>PMID:20463145</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Jiang DH]]
[[Category: Wang K]]