View source for 8xtz


==Crystal structure of Lsd18 in complex with a substrate==
<StructureSection load='8xtz' size='340' side='right'caption='[[8xtz]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8xtz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_lasalocidi Streptomyces lasalocidi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XTZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XTZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1LWM:4-methyl-5-phenyl-3-[(2~{R},3~{S},4~{S},6~{E},10~{E})-2,6,10-triethyl-4-methyl-3-oxidanyl-dodeca-6,10-dienoyl]-1,3-oxazolidin-2-one'>A1LWM</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=ELY:N~6~,N~6~-DIETHYL-L-LYSINE'>ELY</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xtz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xtz OCA], [https://pdbe.org/8xtz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xtz RCSB], [https://www.ebi.ac.uk/pdbsum/8xtz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xtz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LSD18_STRLS LSD18_STRLS] May catalyze the stereoselective double epoxidation reaction leading to bisepoxyprelasalocid A, a bisepoxide intermediate in the biosynthesis of the polyether antibiotic lasalocid A.<ref>PMID:19025863</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Streptomyces lasalocidi]]
[[Category: Chen X]]
[[Category: Deng YM]]
[[Category: Hu YL]]