View source for 8xva


==Human TOM complex with whole Tom20==
<StructureSection load='8xva' size='340' side='right'caption='[[8xva]], [[Resolution|resolution]] 5.92&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8xva]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XVA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.92&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xva OCA], [https://pdbe.org/8xva PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xva RCSB], [https://www.ebi.ac.uk/pdbsum/8xva PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xva ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TOM6_HUMAN TOM6_HUMAN] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The translocase of the outer membrane (TOM) complex serves as the main gate for preproteins entering mitochondria and thus plays a pivotal role in sustaining mitochondrial stability. Precursor proteins, featuring amino-terminal targeting signals (presequences) or internal targeting signals, are recognized by the TOM complex receptors Tom20, Tom22, and Tom70, and then translocated into mitochondria through Tom40. By using chemical cross-linking to stabilize Tom20 in the TOM complex, this study unveils the structure of the human TOM holo complex, encompassing the intact Tom20 component, at a resolution of approximately 6 A by cryo-electron microscopy. Our structure shows the TOM holo complex containing only one Tom20 subunit, which is located right at the center of the complex and stabilized by extensive interactions with Tom22, Tom40, and Tom6. Based on the structure, we proposed a possible translocation mode of TOM complex, by which different receptors could work simultaneously to ensure that the preproteins recognized by them are all efficiently translocated into the mitochondria.

Structure of the intact Tom20 receptor in the human translocase of the outer membrane complex.,Su J, Tian X, Wang Z, Yang J, Sun S, Sui SF PNAS Nexus. 2024 Jul 26;3(7):pgae269. doi: 10.1093/pnasnexus/pgae269. eCollection , 2024 Jul. PMID:39071881<ref>PMID:39071881</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 8xva" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Su JY]]
[[Category: Sui SF]]
[[Category: Tian XY]]