View source for 8xvs


==RNA polymerase II elongation complex with downstream nucleosome extracted from human nuclei==
<StructureSection load='8xvs' size='340' side='right'caption='[[8xvs]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8xvs]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XVS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XVS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xvs OCA], [https://pdbe.org/8xvs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xvs RCSB], [https://www.ebi.ac.uk/pdbsum/8xvs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xvs ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RPB3_HUMAN RPB3_HUMAN] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft (By similarity).<ref>PMID:9852112</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Hirai S]]
[[Category: Kato J]]
[[Category: Kujirai T]]
[[Category: Kurumizaka H]]
[[Category: Negishi L]]
[[Category: Ogasawara M]]
[[Category: Takizawa Y]]
[[Category: Yamamoto K]]