View source for 8xvv


==The TRRAP module of human NuA4/TIP60 complex==
<StructureSection load='8xvv' size='340' side='right'caption='[[8xvv]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8xvv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XVV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XVV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xvv OCA], [https://pdbe.org/8xvv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xvv RCSB], [https://www.ebi.ac.uk/pdbsum/8xvv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xvv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/EP400_HUMAN EP400_HUMAN] Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome.<ref>PMID:14966270</ref> <ref>PMID:24463511</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chen K]]
[[Category: Ren Y]]
[[Category: Wang L]]
[[Category: Wang Q]]
[[Category: Xu Y]]
[[Category: Yu J]]
[[Category: Yu Z]]