View source for 8xwm


==Structure of CXCR2 bound to CXCL6 (Ligand-receptor focused map)==
<StructureSection load='8xwm' size='340' side='right'caption='[[8xwm]], [[Resolution|resolution]] 3.71&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8xwm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XWM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.71&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xwm OCA], [https://pdbe.org/8xwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xwm RCSB], [https://www.ebi.ac.uk/pdbsum/8xwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xwm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CXCL6_HUMAN CXCL6_HUMAN] Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7).<ref>PMID:18443119</ref> <ref>PMID:8399143</ref> <ref>PMID:8423327</ref> <ref>PMID:9057843</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Banerjee R]]
[[Category: Ganguly M]]
[[Category: Nureki O]]
[[Category: Saha S]]
[[Category: Sano FK]]
[[Category: Sharma S]]
[[Category: Shihoya W]]
[[Category: Shukla AK]]