View source for 8xwq


==Cryo-EM structure of ET-1 bound ETBR-DNGI complex==
<StructureSection load='8xwq' size='340' side='right'caption='[[8xwq]], [[Resolution|resolution]] 4.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8xwq]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XWQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XWQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xwq OCA], [https://pdbe.org/8xwq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xwq RCSB], [https://www.ebi.ac.uk/pdbsum/8xwq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xwq ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/EDNRB_HUMAN EDNRB_HUMAN] Hirschsprung disease;Waardenburg-Shah syndrome. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  Defects in EDNRB are associated with Waardenburg syndrome 2, with ocular albinism, autosomal recessive: A disorder characterized by the association of features typical of Waardenburg syndrome type 2 with ocular albinism. Patients manifest reduced visual acuity, albinotic fundus, deafness, hypomelanosis.<ref>PMID:28236341</ref> 
== Function ==
[https://www.uniprot.org/uniprot/EDNRB_HUMAN EDNRB_HUMAN] Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.<ref>PMID:7536888</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Doi T]]
[[Category: Hall M]]
[[Category: Hamaguchi T]]
[[Category: Humbel BM]]
[[Category: Kanno R]]
[[Category: Maki-Yonekura S]]
[[Category: Mizoguchi A]]
[[Category: Negami T]]
[[Category: Tani K]]
[[Category: Terada T]]
[[Category: Yonekura K]]