View source for 8xxi


==Structure of y+LAT1 bound with Leu==
<StructureSection load='8xxi' size='340' side='right'caption='[[8xxi]], [[Resolution|resolution]] 3.04&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8xxi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XXI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XXI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.04&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LEU:LEUCINE'>LEU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xxi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xxi OCA], [https://pdbe.org/8xxi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xxi RCSB], [https://www.ebi.ac.uk/pdbsum/8xxi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xxi ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/YLAT1_HUMAN YLAT1_HUMAN] Lysinuric protein intolerance. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/YLAT1_HUMAN YLAT1_HUMAN] Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids from inside the cells in exchange with neutral amino acids plus sodium ions and may participate in nitric oxide synthesis via the transport of L-arginine (PubMed:10080182, PubMed:10655553, PubMed:14603368, PubMed:15756301, PubMed:15776427, PubMed:17329401, PubMed:9829974, PubMed:9878049). Also mediates arginine transport in non-polarized cells, such as monocytes, and is essential for the correct function of these cells (PubMed:15280038, PubMed:31705628). The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (By similarity). In vitro, Na(+) and Li(+), but also H(+), are cotransported with the neutral amino acids (By similarity).[UniProtKB:Q9R0S5]<ref>PMID:10080182</ref> <ref>PMID:10655553</ref> <ref>PMID:14603368</ref> <ref>PMID:15280038</ref> <ref>PMID:15756301</ref> <ref>PMID:15776427</ref> <ref>PMID:17329401</ref> <ref>PMID:31705628</ref> <ref>PMID:9829974</ref> <ref>PMID:9878049</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Dai L]]
[[Category: Yan RH]]
[[Category: Zhang T]]