View source for 8y7v


==Crystal structure of CP2c/LSF DNA-binding domain==
<StructureSection load='8y7v' size='340' side='right'caption='[[8y7v]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8y7v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Y7V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Y7V FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8y7v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8y7v OCA], [https://pdbe.org/8y7v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8y7v RCSB], [https://www.ebi.ac.uk/pdbsum/8y7v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8y7v ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TFCP2_MOUSE TFCP2_MOUSE] Binds a variety of cellular promoters including fibrinogen, alpha-globin promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter (By similarity).
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Kim SJ]]
[[Category: Lee SH]]
[[Category: Lee SI]]
[[Category: Lee SJ]]
[[Category: Park J]]
[[Category: Won HS]]