View source for 8y8n


==Cryo-EM structure of AQP3 in DDM micelle==
<StructureSection load='8y8n' size='340' side='right'caption='[[8y8n]], [[Resolution|resolution]] 3.12&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8y8n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Y8N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Y8N FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.12&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8y8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8y8n OCA], [https://pdbe.org/8y8n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8y8n RCSB], [https://www.ebi.ac.uk/pdbsum/8y8n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8y8n ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AQP3_RAT AQP3_RAT] Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed:7517548, PubMed:7526388). Could also be permeable to urea (PubMed:7517548, PubMed:7526388). Also participates in cell permeability to H2O2 and H2O2-mediated signaling (By similarity). In skin, transports glycerol to the epidermis and stratum corneum, where it maintains hydration, elasticity, and supports lipid biosynthesis for barrier repair. In kidney, contributes to the reabsorption of water, helping the body maintain proper fluid balance (By similarity).[UniProtKB:Q8R2N1][UniProtKB:Q92482]<ref>PMID:7517548</ref> <ref>PMID:7526388</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Fujiyoshi Y]]
[[Category: Kamegawa A]]
[[Category: Kozai D]]
[[Category: Nishikawa K]]
[[Category: Suzuki H]]
[[Category: Suzuki S]]