View source for 8yal


==ATAT-2 bound K40Q MEC-12/MEC-7 microtubule==
<StructureSection load='8yal' size='340' side='right'caption='[[8yal]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8yal]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YAL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YAL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=G2P:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>G2P</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8yal FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8yal OCA], [https://pdbe.org/8yal PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8yal RCSB], [https://www.ebi.ac.uk/pdbsum/8yal PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8yal ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TBA3_CAEEL TBA3_CAEEL] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Component of the large-diameter neuronal microtubules which contains 15 protofilaments (PubMed:9885292). Plays a role in mechanosensory transduction (touch sensitivity) (PubMed:19652181, PubMed:9885292).<ref>PMID:19652181</ref> <ref>PMID:9885292</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Caenorhabditis elegans]]
[[Category: Large Structures]]
[[Category: Lam WH]]
[[Category: Ti S]]
[[Category: Yu D]]
[[Category: Zhai Y]]