View source for 8ycx


==CryoEM structure of M. tuberculosis ClpC1P1P2 complex bound to bortezomib, conformation 2==
<StructureSection load='8ycx' size='340' side='right'caption='[[8ycx]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8ycx]] is a 21 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_grunniens Bos grunniens] and [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YCX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YCX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=BO2:N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE'>BO2</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ycx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ycx OCA], [https://pdbe.org/8ycx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ycx RCSB], [https://www.ebi.ac.uk/pdbsum/8ycx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ycx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CLPC1_MYCTU CLPC1_MYCTU] ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity). Degrades anti-sigma-E factor RseA in the presence of ClpP2.
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</StructureSection>
[[Category: Bos grunniens]]
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Chen X]]
[[Category: Gao Y]]
[[Category: He J]]
[[Category: Xiong X]]
[[Category: Zhang T]]
[[Category: Zhao H]]
[[Category: Zhou B]]