View source for 8ydd


==Crystal structure of Nanog(R100A) in complex with Wdr5==
<StructureSection load='8ydd' size='340' side='right'caption='[[8ydd]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8ydd]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YDD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YDD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ydd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ydd OCA], [https://pdbe.org/8ydd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ydd RCSB], [https://www.ebi.ac.uk/pdbsum/8ydd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ydd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/WDR5_MOUSE WDR5_MOUSE] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (By similarity).
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</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Chen Y]]
[[Category: Shi X]]
[[Category: Wang D]]
[[Category: Wu B]]
[[Category: Zhao L]]