View source for 8yef


==HPV6 L1 pentamer in complex with Fab F5-77==
<StructureSection load='8yef' size='340' side='right'caption='[[8yef]], [[Resolution|resolution]] 4.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8yef]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Alphapapillomavirus_10 Alphapapillomavirus 10] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YEF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YEF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8yef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8yef OCA], [https://pdbe.org/8yef PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8yef RCSB], [https://www.ebi.ac.uk/pdbsum/8yef PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8yef ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VL1_HPV6A VL1_HPV6A] Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.[HAMAP-Rule:MF_04002]
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</StructureSection>
[[Category: Alphapapillomavirus 10]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Fu W]]
[[Category: Wang X]]