View source for 8yhv


==Structure of the VP40 from Biortus.==
<StructureSection load='8yhv' size='340' side='right'caption='[[8yhv]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8yhv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ebola_virus_-_Zaire_(1995) Ebola virus - Zaire (1995)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YHV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YHV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8yhv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8yhv OCA], [https://pdbe.org/8yhv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8yhv RCSB], [https://www.ebi.ac.uk/pdbsum/8yhv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8yhv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VP40_EBOZ5 VP40_EBOZ5] Plays an essential role virus particle assembly and budding. Acts by interacting with viral ribonucleocapsid and host members of the ESCRT (endosomal sorting complex required for transport) system such as host VPS4, PDCD6IP/ALIX, NEDD4 or TGS101. The interaction with host E3 ubiquitin ligase SMURF2 also facilitates virus budding. May play a role in immune cell dysfunction by being packaged into exosomes that can decrease the viability of recipient cells (via RNAi suppression and exosome-bystander apoptosis).[UniProtKB:Q05128]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Cheng W]]
[[Category: Lv Z]]
[[Category: Meng Q]]
[[Category: Wang F]]
[[Category: Zhang B]]