View source for 8yiy


==Cryo-EM structure of human proteasome assembly intermediate preholo-1==
<StructureSection load='8yiy' size='340' side='right'caption='[[8yiy]], [[Resolution|resolution]] 3.41&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8yiy]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YIY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YIY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.41&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8yiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8yiy OCA], [https://pdbe.org/8yiy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8yiy RCSB], [https://www.ebi.ac.uk/pdbsum/8yiy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8yiy ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PSA2_HUMAN PSA2_HUMAN] The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMA2 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Han Q]]
[[Category: Han Y]]
[[Category: Liu K]]
[[Category: Tang Q]]
[[Category: Zhang Y]]