View source for 8yiz


==Cryo-EM structure of human proteasome assembly intermediate preholo-2==
<StructureSection load='8yiz' size='340' side='right'caption='[[8yiz]], [[Resolution|resolution]] 3.79&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8yiz]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YIZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YIZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.79&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8yiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8yiz OCA], [https://pdbe.org/8yiz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8yiz RCSB], [https://www.ebi.ac.uk/pdbsum/8yiz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8yiz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PSA2_HUMAN PSA2_HUMAN] The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMA2 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Han Q]]
[[Category: Han Y]]
[[Category: Liu K]]
[[Category: Tang Q]]
[[Category: Zhang Y]]