View source for 8ymk


==Localized reconstruction of Hepatitis B virus surface antigen dimer in the subviral particle with D2 symmetry from dataset A0==
<StructureSection load='8ymk' size='340' side='right'caption='[[8ymk]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8ymk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_B_virus_ayw/China/Tibet127/2002 Hepatitis B virus ayw/China/Tibet127/2002]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YMK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YMK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ymk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ymk OCA], [https://pdbe.org/8ymk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ymk RCSB], [https://www.ebi.ac.uk/pdbsum/8ymk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ymk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HBSAG_HBVC7 HBSAG_HBVC7] The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assures fusion between virion membrane and endosomal membrane. In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein.[HAMAP-Rule:MF_04075]  The middle envelope protein plays an important role in the budding of the virion. It is involved in the induction of budding in a nucleocapsid independent way. In this process the majority of envelope proteins bud to form subviral lipoprotein particles of 22 nm of diameter that do not contain a nucleocapsid.[HAMAP-Rule:MF_04075]
__TOC__
</StructureSection>
[[Category: Hepatitis B virus ayw/China/Tibet127/2002]]
[[Category: Large Structures]]
[[Category: Cao L]]
[[Category: Mu A]]
[[Category: Rao ZH]]
[[Category: Wang Q]]
[[Category: Wang T]]