View source for 8ype


==The crystal structure of inactive p38 complexed with a ATF2 from 46 to 80==
<StructureSection load='8ype' size='340' side='right'caption='[[8ype]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8ype]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YPE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YPE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ype FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ype OCA], [https://pdbe.org/8ype PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ype RCSB], [https://www.ebi.ac.uk/pdbsum/8ype PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ype ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ATF2_HUMAN ATF2_HUMAN] Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2/JUN complex.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: He QQ]]
[[Category: Luo ZP]]
[[Category: Pei CJ]]
[[Category: Wang ZX]]
[[Category: Wu JW]]
[[Category: Zhang YY]]