View source for 8yqq


==Structure of HKU1B RBD with TMPRSS2==
<StructureSection load='8yqq' size='340' side='right'caption='[[8yqq]], [[Resolution|resolution]] 3.95&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8yqq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candidatus_Accumulibacter_adiacens Candidatus Accumulibacter adiacens] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YQQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YQQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.95&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8yqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8yqq OCA], [https://pdbe.org/8yqq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8yqq RCSB], [https://www.ebi.ac.uk/pdbsum/8yqq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8yqq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SPIKE_CVHN5 SPIKE_CVHN5] S1 attaches the virion to the cell membrane by interacting with cell receptors, initiating the infection.  S2 is a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Presumably interacts with target cell lipid raft after cell attachment (By similarity).
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</StructureSection>
[[Category: Candidatus Accumulibacter adiacens]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cui S]]
[[Category: Ding W]]
[[Category: Gao X]]
[[Category: Shang K]]
[[Category: Zhu H]]
[[Category: Zhu K]]