View source for 8yra


==The Cyro-EM Structure of human SLC26A3 with specific inhibitor DRAinh-A250==
<StructureSection load='8yra' size='340' side='right'caption='[[8yra]], [[Resolution|resolution]] 3.78&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8yra]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YRA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YRA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.78&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1LZR:2-[7-[(3-bromophenyl)methoxy]-4,8-dimethyl-2-oxidanylidene-chromen-3-yl]ethanoic+acid'>A1LZR</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8yra FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8yra OCA], [https://pdbe.org/8yra PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8yra RCSB], [https://www.ebi.ac.uk/pdbsum/8yra PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8yra ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/S26A3_HUMAN S26A3_HUMAN] Congenital chloride diarrhea. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/S26A3_HUMAN S26A3_HUMAN] Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia (PubMed:16606687, PubMed:19321737, PubMed:22159084, PubMed:22627094). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity).[UniProtKB:Q9WVC8]<ref>PMID:16606687</ref> <ref>PMID:19321737</ref> <ref>PMID:22159084</ref> <ref>PMID:22627094</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Dang S]]
[[Category: Feng JR]]