View source for 8yrj


==Mouse Fc epsilon RI==
<StructureSection load='8yrj' size='340' side='right'caption='[[8yrj]], [[Resolution|resolution]] 3.87&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8yrj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YRJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YRJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.87&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8yrj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8yrj OCA], [https://pdbe.org/8yrj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8yrj RCSB], [https://www.ebi.ac.uk/pdbsum/8yrj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8yrj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FCERA_MOUSE FCERA_MOUSE] High-affinity receptor for immunoglobulin epsilon/IgE. Mediates IgE effector functions in myeloid cells. Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation. On mast cells, basophils and eosinophils stimulates the secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes. Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity. When dysregulated, it can elicit harmful life-threatening allergic and anaphylactic reactions.[UniProtKB:P12319]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Ohto U]]
[[Category: Shimizu T]]
[[Category: Yui M]]
[[Category: Zhang Z]]