View source for 8ys8


==The Cyro-EM Structure of human SLC26A3 with non-specific inhibitor Tenidap==
<StructureSection load='8ys8' size='340' side='right'caption='[[8ys8]], [[Resolution|resolution]] 3.79&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8ys8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YS8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YS8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.79&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I2U:5-chloranyl-2-oxidanyl-3-thiophen-2-ylcarbonyl-indole-1-carboxamide'>I2U</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ys8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ys8 OCA], [https://pdbe.org/8ys8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ys8 RCSB], [https://www.ebi.ac.uk/pdbsum/8ys8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ys8 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/S26A3_HUMAN S26A3_HUMAN] Congenital chloride diarrhea. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/S26A3_HUMAN S26A3_HUMAN] Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia (PubMed:16606687, PubMed:19321737, PubMed:22159084, PubMed:22627094). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity).[UniProtKB:Q9WVC8]<ref>PMID:16606687</ref> <ref>PMID:19321737</ref> <ref>PMID:22159084</ref> <ref>PMID:22627094</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Dang S]]
[[Category: Feng JR]]