View source for 8yw3


==Cryo-EM structure of the retatrutide-bound human GLP-1R-Gs complex==
<StructureSection load='8yw3' size='340' side='right'caption='[[8yw3]], [[Resolution|resolution]] 2.68&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8yw3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YW3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.68&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2ML:2-METHYLLEUCINE'>2ML</scene>, <scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8yw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8yw3 OCA], [https://pdbe.org/8yw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8yw3 RCSB], [https://www.ebi.ac.uk/pdbsum/8yw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8yw3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GBB1_HUMAN GBB1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<ref>PMID:18611381</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Cong ZT]]
[[Category: Li WX]]
[[Category: Li WZ]]
[[Category: Wang MW]]
[[Category: Xu HE]]
[[Category: Yang DH]]
[[Category: Yuan QN]]
[[Category: Zhao FH]]
[[Category: Zhao LH]]
[[Category: Zhou QT]]