View source for 8yw8


==Cryo-EM structure of human mitochondrial pyruvate carrier in complex with the inhibitor UK5099==
<StructureSection load='8yw8' size='340' side='right'caption='[[8yw8]], [[Resolution|resolution]] 3.17&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8yw8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BL21(DE3) Escherichia coli BL21(DE3)] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YW8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YW8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.17&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=I2R:(~{E})-2-cyano-3-(1-phenylindol-3-yl)prop-2-enoic+acid'>I2R</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8yw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8yw8 OCA], [https://pdbe.org/8yw8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8yw8 RCSB], [https://www.ebi.ac.uk/pdbsum/8yw8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8yw8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MPC2_HUMAN MPC2_HUMAN] Mediates the uptake of pyruvate into mitochondria.<ref>PMID:22628558</ref> <ref>PMID:26253029</ref> <ref>PMID:27317664</ref> <ref>PMID:29472561</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Liang JM]]
[[Category: Ma D]]
[[Category: Shi JH]]