View source for 8yy6


==Structure of a murine monoclonal antibody Fab5 targeting Epstein-Barr virus gB==
<StructureSection load='8yy6' size='340' side='right'caption='[[8yy6]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8yy6]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_4 Human gammaherpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YY6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8yy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8yy6 OCA], [https://pdbe.org/8yy6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8yy6 RCSB], [https://www.ebi.ac.uk/pdbsum/8yy6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8yy6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/R4R670_EBVG R4R670_EBVG] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
EpsteinâBarr virus (EBV) is a ubiquitous gammaherpesvirus linked to a broad spectrum of malignancies and autoimmune diseases with no approved therapeutic drugs or vaccines. EBV infection relies on the viral glycoproteins gB and gHgL, which, together, function as the fusion apparatus, mediating viral recognition and membrane fusion in both epithelial and B cells. Despite discovering potent neutralizing antibodies targeting gB and gHgL, the heterogeneous antigen structures and distribution of multiple glycoproteins in the virion hinder rational vaccine design targeting this apparatus complex. In this study, Chimeric nanoparticles (Chimeric-NPs) are designed that co-display EBV fusion apparatus and induce significantly more neutralizing antibodies in mice and nonhuman primates than the cocktail counterparts. It is further demonstrated that the Chimeric-NPs elicited neutralizing antibodies predominantly targeting gB, closely mimicking the antibody induction pattern by the whole EBV virion. Additionally, single-BCR sequencing is used to analyze the B cell response to Chimeric-NP, and a novel gB neutralizing antibody Fab5 targeting a new vulnerable site EBV gB is identified. These findings provide novel candidates and vaccine design strategies for EBV and reveal the underlying mechanisms of antibody induction and immune response regulation by chimera vaccines, with potential implications for all multi-antigen-harbored pathogens.

Chimeric Glycoprotein Nanoparticles Elicit Robust Neutralizing Antibodies Against Epstein-Barr Virus.,Sun C, Xie C, Fang XY, Hong DC, Zhang H, Wu PH, Liu YN, Bu GL, Cao DH, Si-Tu MY, Peng YJ, Wang J, Feng GK, Zhong Q, Liu Z, Zeng MS Adv Mater. 2025 Oct 4:e07012. doi: 10.1002/adma.202507012. PMID:41045177<ref>PMID:41045177</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 8yy6" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Human gammaherpesvirus 4]]
[[Category: Large Structures]]
[[Category: Fang XY]]
[[Category: Liu Z]]
[[Category: Sun C]]
[[Category: Zeng MS]]