View source for 8z4a


==Solution Structure of DRB4 C-terminal domain, DRB4D3==
<StructureSection load='8z4a' size='340' side='right'caption='[[8z4a]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8z4a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Z4A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Z4A FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8z4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8z4a OCA], [https://pdbe.org/8z4a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8z4a RCSB], [https://www.ebi.ac.uk/pdbsum/8z4a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8z4a ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DRB4_ARATH DRB4_ARATH] Double-stranded RNA-binding protein involved in RNA-mediated post-transcriptional gene silencing (PTGS). Functions in the trans-acting small interfering RNAs (ta-siRNAs) biogenesis by binding and assisting DICER-LIKE 4 (DCL4). Required for DCL4 activity. Required for the 21 nucleotide ta-siRNAs production of the TAS3 transcript in leaves but not in flowers. Plays an important role in silencing RNA of both DNA and RNA viruses. Involved with argonaute 7 (AGO7) and RDR6 in turnip crinkle virus (TCV) silencing. May not be directly involved in viral siRNA production. May stabilize the 21 nucleotide viral siRNAs and deliver them to the RISC complex. Targeted by the viral silencing suppressor (VSR) transactivator/viroplasmin (TAV) protein of the cauliflower mosaic virus (CaMV) that inactivates DRB4 function in RNA silencing. Probably not involved in the guide strand selection from RNA duplexes. Involved in leaf morphology through its function in ta-siRNA-mediated silencing.<ref>PMID:16682354</ref> <ref>PMID:17221360</ref> <ref>PMID:18625233</ref> <ref>PMID:18799732</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Large Structures]]
[[Category: Deshmukh MV]]
[[Category: Patra D]]
[[Category: Paturi S]]