View source for 8z9m


==Cryo-EM structure of dimeric WDR11-FAM91A1 complex==
<StructureSection load='8z9m' size='340' side='right'caption='[[8z9m]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8z9m]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Z9M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Z9M FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8z9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8z9m OCA], [https://pdbe.org/8z9m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8z9m RCSB], [https://www.ebi.ac.uk/pdbsum/8z9m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8z9m ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/F91A1_HUMAN F91A1_HUMAN] As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1.<ref>PMID:29426865</ref> 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Vesicle trafficking is a fundamental process that allows for the sorting and transport of specific proteins (i.e., "cargoes") to different compartments of eukaryotic cells. Cargo recognition primarily occurs through coats and the associated proteins at the donor membrane. However, it remains unclear whether cargoes can also be selected at other stages of vesicle trafficking to further enhance the fidelity of the process. The WDR11-FAM91A1 complex functions downstream of the clathrin-associated AP-1 complex to facilitate protein transport from endosomes to the TGN. Here, we report the cryo-EM structure of human WDR11-FAM91A1 complex. WDR11 directly and specifically recognizes a subset of acidic clusters, which we term super acidic clusters (SACs). WDR11 complex assembly and its binding to SAC-containing proteins are indispensable for the trafficking of SAC-containing proteins and proper neuronal development in zebrafish. Our studies thus uncover that cargo proteins could be recognized in a sequence-specific manner downstream of a protein coat.

The WDR11 complex is a receptor for acidic-cluster-containing cargo proteins.,Deng H, Jia G, Li P, Tang Y, Zhao L, Yang Q, Zhao J, Wang J, Tu Y, Yong X, Zhang S, Mo X, Billadeau DD, Su Z, Jia D Cell. 2024 Aug 8;187(16):4272-4288.e20. doi: 10.1016/j.cell.2024.06.024. Epub , 2024 Jul 15. PMID:39013469<ref>PMID:39013469</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 8z9m" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Deng QH]]
[[Category: Jia D]]
[[Category: Jia GW]]
[[Category: Su ZM]]