View source for 8z9o


==Cryo-EM structure of human GPR4-Gs complex==
<StructureSection load='8z9o' size='340' side='right'caption='[[8z9o]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8z9o]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Z9O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Z9O FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8z9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8z9o OCA], [https://pdbe.org/8z9o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8z9o RCSB], [https://www.ebi.ac.uk/pdbsum/8z9o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8z9o ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GBB1_RAT GBB1_RAT] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
__TOC__
</StructureSection>
[[Category: Bos taurus]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Synthetic construct]]
[[Category: Cai XJ]]
[[Category: Chai R]]
[[Category: Chen LN]]
[[Category: Cheng SZ]]
[[Category: Fu YF]]
[[Category: Han F]]
[[Category: Ji SY]]
[[Category: Liu YF]]
[[Category: Ma XY]]
[[Category: Mao CY]]
[[Category: Shen DD]]
[[Category: Shen QY]]
[[Category: Wang WW]]
[[Category: Xu P]]
[[Category: Yang L]]
[[Category: Zhang HB]]
[[Category: Zhang M]]
[[Category: Zhang Y]]