View source for 8zac


==Crystal structure of BcABA3 from Botrytis cinerea==
<StructureSection load='8zac' size='340' side='right'caption='[[8zac]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8zac]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Botrytis_cinerea_B05.10 Botrytis cinerea B05.10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ZAC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ZAC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8zac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8zac OCA], [https://pdbe.org/8zac PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8zac RCSB], [https://www.ebi.ac.uk/pdbsum/8zac PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8zac ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ABA3_BOTFB ABA3_BOTFB] Alpha-ionylideneethane synthase; part of the gene cluster that mediates the biosynthesis of abscisic acid (ABA), a phytohormone that acts antagonistically toward salicylic acid (SA), jasmonic acid (JA) and ethylene (ETH) signaling, to impede plant defense responses (PubMed:15240257, PubMed:16820452). The first step of the pathway catalyzes the reaction from farnesyl diphosphate to alpha-ionylideneethane performed by the alpha-ionylideneethane synthase aba3 via a three-step reaction mechanism involving 2 neutral intermediates, beta-farnesene and allofarnesene (PubMed:30226766). The cytochrome P450 monooxygenase aba1 might then be involved in the conversion of alpha-ionylideneethane to alpha-ionylideneacetic acid (Probable). Alpha-ionylideneacetic acid is further converted to abscisic acid in 2 steps involving the cytochrome P450 monooxygenase aba2 and the short-chain dehydrogenase/reductase aba4, via the intermediates 1'-deoxy-ABA or 1',4'-trans-diol-ABA, depending on the order of action of these 2 enzymes (Probable). Aba2 is responsible for the hydroxylation of carbon atom C-1' and aba4 might be involved in the oxidation of the C-4' carbon atom (PubMed:16820452).<ref>PMID:15240257</ref> <ref>PMID:16820452</ref> <ref>PMID:30226766</ref> <ref>PMID:16820452</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Botrytis cinerea B05 10]]
[[Category: Large Structures]]
[[Category: Chen C-C]]
[[Category: Guo R-T]]
[[Category: Huang J-W]]
[[Category: Li H]]
[[Category: Li SY]]
[[Category: Yang Y]]