View source for 8zat


==Cryo-EM structure of human SLC15A3 (apo)==
<StructureSection load='8zat' size='340' side='right'caption='[[8zat]], [[Resolution|resolution]] 3.54&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8zat]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ZAT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ZAT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.54&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8zat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8zat OCA], [https://pdbe.org/8zat PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8zat RCSB], [https://www.ebi.ac.uk/pdbsum/8zat PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8zat ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/S15A3_HUMAN S15A3_HUMAN] Proton-coupled amino-acid transporter that transports free histidine and certain di- and tripeptides, and is involved in innate immune response (By similarity). Also able to transport carnosine (PubMed:31073693, PubMed:31254495). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (By similarity).[UniProtKB:Q8BPX9]<ref>PMID:31073693</ref> <ref>PMID:31254495</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Kasai S]]
[[Category: Ohto U]]
[[Category: Shimizu T]]
[[Category: Zhang Z]]