View source for 8zgb


==W-degron fused ZZ-domain of the Arabidopsis thaliana E3 ubiquitin-protein ligase PRT1==
<StructureSection load='8zgb' size='340' side='right'caption='[[8zgb]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8zgb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ZGB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ZGB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.785&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8zgb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8zgb OCA], [https://pdbe.org/8zgb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8zgb RCSB], [https://www.ebi.ac.uk/pdbsum/8zgb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8zgb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PRT1_ARATH PRT1_ARATH] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. Functions in the N-end rule pathway of protein degradation, where it specifically recognizes and ubiquitinates proteins with a N-terminal bulky aromatic amino acid (Phe). Does not act on aliphatic hydrophobic and basic N-terminal residues (Arg or Leu) containing proteins.<ref>PMID:11607348</ref> <ref>PMID:14551326</ref> <ref>PMID:17572409</ref> <ref>PMID:9653113</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Large Structures]]
[[Category: Song HK]]
[[Category: Yang WS]]