View source for 8zhv


==Structure of 3-amino-3-carboxyltransferase in complex with SAH and nocardicin G in the biosynthesis of nocardicins==
<StructureSection load='8zhv' size='340' side='right'caption='[[8zhv]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8zhv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Nocardia_uniformis_subsp._tsuyamanensis Nocardia uniformis subsp. tsuyamanensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ZHV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ZHV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.13&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1L1U:(2~{R})-2-[(3~{S})-3-[[(2~{R})-2-azanyl-2-(4-hydroxyphenyl)ethanoyl]amino]-2-oxidanylidene-azetidin-1-yl]-2-(4-hydroxyphenyl)ethanoic+acid'>A1L1U</scene>, <scene name='pdbligand=A4D:5-THIOADENOSINE'>A4D</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8zhv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8zhv OCA], [https://pdbe.org/8zhv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8zhv RCSB], [https://www.ebi.ac.uk/pdbsum/8zhv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8zhv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NAT_NOCUT NAT_NOCUT] Involved in the biosynthesis of the beta-lactam antibiotic nocardicin A (PubMed:9804844). In the presence of S-adenosyl-L-methionine (AdoMet), catalyzes the transfer of a 3-amino-3-carboxypropyl group from AdoMet to nocardicin G, forming isonocardicin C (PubMed:9804844). Can also catalyze the transformation of nocardicin E and F to isonocardicin A and B, respectively, but in vivo substrate is probably nocardicin G (PubMed:9804844).<ref>PMID:9804844</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Nocardia uniformis subsp. tsuyamanensis]]
[[Category: Abe I]]
[[Category: Awakawa T]]
[[Category: Gao Y]]
[[Category: Mori T]]