View source for 8zkn


==CryoEM structure of Thyroid Hormone Transporter MCT8 bound with silychristin==
<StructureSection load='8zkn' size='340' side='right'caption='[[8zkn]], [[Resolution|resolution]] 3.06&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8zkn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ZKN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ZKN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.06&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1IET:(2~{R},3~{R})-2-[(2~{S},3~{R})-3-(hydroxymethyl)-2-(3-methoxy-4-oxidanyl-phenyl)-7-oxidanyl-2,3-dihydro-1-benzofuran-5-yl]-3,5,7-tris(oxidanyl)-2,3-dihydrochromen-4-one'>A1IET</scene>, <scene name='pdbligand=DU0:2-[2-[(1~{S},2~{S},4~{S},5~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5,7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2-oxane]-16-yl]oxyethyl]propane-1,3-diol'>DU0</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8zkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8zkn OCA], [https://pdbe.org/8zkn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8zkn RCSB], [https://www.ebi.ac.uk/pdbsum/8zkn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8zkn ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/MOT8_HUMAN MOT8_HUMAN] Allan-Herndon-Dudley syndrome. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/MOT8_HUMAN MOT8_HUMAN] Specific thyroid hormone transmembrane transporter, that mediates both uptake and efflux of thyroid hormones across the cell membrane independently of pH or a Na(+) gradient. Major substrates are the iodothyronines T3 and T4 and to a lesser extent rT3 and 3,3-diiodothyronine (3,3'-T2) (PubMed:16887882, PubMed:18337592, PubMed:20628049, PubMed:23550058, PubMed:26426690, PubMed:27805744, PubMed:31436139). Acts as an important mediator of thyroid hormone transport, especially T3, through the blood-brain barrier (Probable) (PubMed:28526555).<ref>PMID:16887882</ref> <ref>PMID:18337592</ref> <ref>PMID:20628049</ref> <ref>PMID:23550058</ref> <ref>PMID:26426690</ref> <ref>PMID:27805744</ref> <ref>PMID:28526555</ref> <ref>PMID:31436139</ref> <ref>PMID:18636565</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Kong F]]
[[Category: Qian J]]
[[Category: Tan J]]
[[Category: Xiao Y]]
[[Category: Yan C]]
[[Category: Zhu A]]