View source for 8zko


==CryoEM structure of Thyroid Hormone Transporter MCT8==
<StructureSection load='8zko' size='340' side='right'caption='[[8zko]], [[Resolution|resolution]] 3.13&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8zko]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ZKO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ZKO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.13&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene>, <scene name='pdbligand=T3:3,5,3TRIIODOTHYRONINE'>T3</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8zko FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8zko OCA], [https://pdbe.org/8zko PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8zko RCSB], [https://www.ebi.ac.uk/pdbsum/8zko PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8zko ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/MOT8_HUMAN MOT8_HUMAN] Allan-Herndon-Dudley syndrome. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/MOT8_HUMAN MOT8_HUMAN] Specific thyroid hormone transmembrane transporter, that mediates both uptake and efflux of thyroid hormones across the cell membrane independently of pH or a Na(+) gradient. Major substrates are the iodothyronines T3 and T4 and to a lesser extent rT3 and 3,3-diiodothyronine (3,3'-T2) (PubMed:16887882, PubMed:18337592, PubMed:20628049, PubMed:23550058, PubMed:26426690, PubMed:27805744, PubMed:31436139). Acts as an important mediator of thyroid hormone transport, especially T3, through the blood-brain barrier (Probable) (PubMed:28526555).<ref>PMID:16887882</ref> <ref>PMID:18337592</ref> <ref>PMID:20628049</ref> <ref>PMID:23550058</ref> <ref>PMID:26426690</ref> <ref>PMID:27805744</ref> <ref>PMID:28526555</ref> <ref>PMID:31436139</ref> <ref>PMID:18636565</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Kong F]]
[[Category: Qian J]]
[[Category: Tan J]]
[[Category: Xiao Y]]
[[Category: Yan C]]
[[Category: Zhu A]]