View source for 8zmc


==Dengue 3 NS5 methyltransferase bound to S-Adenosyl-L-homocysteine and Herbacetin==
<StructureSection load='8zmc' size='340' side='right'caption='[[8zmc]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8zmc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_3 Dengue virus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ZMC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ZMC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1L1Z:2-(4-hydroxyphenyl)-3,5,7,8-tetrakis(oxidanyl)chromen-4-one'>A1L1Z</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8zmc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8zmc OCA], [https://pdbe.org/8zmc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8zmc RCSB], [https://www.ebi.ac.uk/pdbsum/8zmc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8zmc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/C1KBQ3_9FLAV C1KBQ3_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]
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</StructureSection>
[[Category: Dengue virus 3]]
[[Category: Large Structures]]
[[Category: Bhutkar M]]
[[Category: Kumar P]]
[[Category: Tomar S]]
[[Category: Verma S]]