View source for 8zsb


==Cryo-EM structure of human ZnT1, in the absence of zinc, determined in outward-facing conformation==
<StructureSection load='8zsb' size='340' side='right'caption='[[8zsb]], [[Resolution|resolution]] 3.26&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8zsb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ZSB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ZSB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.26&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8zsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8zsb OCA], [https://pdbe.org/8zsb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8zsb RCSB], [https://www.ebi.ac.uk/pdbsum/8zsb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8zsb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ZNT1_HUMAN ZNT1_HUMAN] Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity (PubMed:31471319). Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism. By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells. By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells (By similarity). In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles. In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them (PubMed:32441444).[UniProtKB:Q62720]<ref>PMID:31471319</ref> <ref>PMID:32441444</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Ma J]]
[[Category: Zheng S]]