View source for 8zt1


==sStructure of calcium preference ATP-gated channel P2X1 in complex with BTFA==
<StructureSection load='8zt1' size='340' side='right'caption='[[8zt1]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8zt1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ZT1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ZT1 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1D8Z:3,5-bis(trifluoromethyl)aniline'>A1D8Z</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8zt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8zt1 OCA], [https://pdbe.org/8zt1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8zt1 RCSB], [https://www.ebi.ac.uk/pdbsum/8zt1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8zt1 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/P2RX1_MOUSE P2RX1_MOUSE] ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and with relatively high calcium permeability (By similarity). Furthermore, CTP functions as a weak affinity agonist for P2RX1 (By similarity). Plays a role in male fertility, bladder contraction and platelet aggregation (PubMed:10638758, PubMed:11090125, PubMed:19635923, PubMed:25150292). Specifically, plays an important role in neurogenic contraction of smooth muscle of the vas deferens, and therefore is essential for normal male reproductive function (PubMed:10638758). In addition, contributes to smooth muscle contractions of the urinary bladder (PubMed:11090125). On platelets, contributes to platelet activation and aggregation and thereby, also to thrombosis (PubMed:25150292). On neutrophils, it is involved in chemotaxis and in mitigating the activation of circulating cells (PubMed:19635923).[UniProtKB:P51575]<ref>PMID:10638758</ref> <ref>PMID:11090125</ref> <ref>PMID:19635923</ref> <ref>PMID:25150292</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Xu HE]]
[[Category: Zhang H]]