View source for 8zwo


==Structure of CTF18-PCNA with ATP==
<StructureSection load='8zwo' size='340' side='right'caption='[[8zwo]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8zwo]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ZWO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ZWO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.99&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8zwo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8zwo OCA], [https://pdbe.org/8zwo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8zwo RCSB], [https://www.ebi.ac.uk/pdbsum/8zwo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8zwo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CTF18_HUMAN CTF18_HUMAN] Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. Interacts with and stimulates DNA polymerase POLH. During DNA repair synthesis, involved in loading DNA polymerase POLE at the sites of local damage (PubMed:20227374).<ref>PMID:12766176</ref> <ref>PMID:12930902</ref> <ref>PMID:17545166</ref> <ref>PMID:20227374</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Al-Amodi A]]
[[Category: Briola GR]]
[[Category: De Biasio A]]
[[Category: Hamdan SM]]
[[Category: Nguyen PQ]]
[[Category: Savva CG]]
[[Category: Tehseen M]]