View source for 8zxc


==NMR solution structures of ASH1L BRD-PHD domain in complex with H3K4me2 peptide==
<StructureSection load='8zxc' size='340' side='right'caption='[[8zxc]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8zxc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ZXC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ZXC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8zxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8zxc OCA], [https://pdbe.org/8zxc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8zxc RCSB], [https://www.ebi.ac.uk/pdbsum/8zxc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8zxc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/H3C_HUMAN H3C_HUMAN] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Hominid-specific H3.5/H3F3C preferentially colocalizes with euchromatin, and it is associated with actively transcribed genes.<ref>PMID:21274551</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Zeng L]]
[[Category: Zhou M-M]]